Patients with cleft palate with ankyloglossia may have both of these features or cleft palate alone or ankyloglossia alone. It is inherited in an X-linked recessive manner with variable expression in heterozygous females. It is unknown the percentage of affected patients who have a mutation in TBX22.
This laboratory performs Sanger sequencing of the TBX22 gene.
Cleft palate with ankyloglossia